Brain atrophy and white matter hyperintensities in early Parkinson's disease
Identifieur interne : 000514 ( Main/Corpus ); précédent : 000513; suivant : 000515Brain atrophy and white matter hyperintensities in early Parkinson's disease
Auteurs : Turi O. Dalaker ; Jan P. Larsen ; Niels Bergsland ; Mona K. Beyer ; Guido Alves ; Michael G. Dwyer ; Ole-Bjorn Tysnes ; Ralph H. B. Benedict ; Arpad Kelemen ; Kolbjorn Bronnick ; Robert ZivadinovSource :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
English descriptors
Abstract
The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22754
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Dwyer</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Bronnick, Kolbjorn" sort="Bronnick, Kolbjorn" uniqKey="Bronnick K" first="Kolbjorn" last="Bronnick">Kolbjorn Bronnick</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C02DE818BF537E2F5D675023C45334276547BA43</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22754</idno><idno type="url">https://api.istex.fr/document/C02DE818BF537E2F5D675023C45334276547BA43/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000514</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Brain atrophy and white matter hyperintensities in early Parkinson's disease</title><author><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name><affiliation><mods:affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</mods:affiliation></affiliation></author><author><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Bronnick, Kolbjorn" sort="Bronnick, Kolbjorn" uniqKey="Bronnick K" first="Kolbjorn" last="Bronnick">Kolbjorn Bronnick</name><affiliation><mods:affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><affiliation><mods:affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15">2009-11-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2233">2233</biblScope><biblScope unit="page" to="2241">2241</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C02DE818BF537E2F5D675023C45334276547BA43</idno><idno type="DOI">10.1002/mds.22754</idno><idno type="ArticleID">MDS22754</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MRI</term><term>Parkinson's disease</term><term>SIENAX</term><term>brain atrophy</term><term>cognition</term><term>white matter hyperintensities</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Turi O. Dalaker MD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jan P. Larsen MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Niels Bergsland BA</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Mona K. Beyer MD, PhD</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Guido Alves MD, PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Michael G. Dwyer BS</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Ole‐Bjorn Tysnes MD, PhD</name><affiliations><json:string>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</json:string><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Ralph H.B. Benedict PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Arpad Kelemen PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item><json:item><name>Kolbjorn Bronnick PhD</name><affiliations><json:string>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Robert Zivadinov MD, PhD</name><affiliations><json:string>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</json:string><json:string>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SIENAX</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>white matter hyperintensities</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item></subject><articleId><json:string>MDS22754</json:string></articleId><language><json:string>eng</json:string></language><abstract>The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. 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No. # 186966;</note><note>Norwegian Society of Radiology</note><note>Norwegian ParkWest</note><note>Western Norway Regional Health Authority - No. # 911218;</note><note>Research Council of Norway - No. # 177966;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Brain atrophy and white matter hyperintensities in early Parkinson's disease</title><author><persName><forename type="first">Turi O.</forename><surname>Dalaker</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jan P.</forename><surname>Larsen</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation></author><author><persName><forename type="first">Niels</forename><surname>Bergsland</surname></persName><roleName type="degree">BA</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Mona K.</forename><surname>Beyer</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Guido</forename><surname>Alves</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Michael G.</forename><surname>Dwyer</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Ole‐Bjorn</forename><surname>Tysnes</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Ralph H.B.</forename><surname>Benedict</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Arpad</forename><surname>Kelemen</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author><author><persName><forename type="first">Kolbjorn</forename><surname>Bronnick</surname></persName><roleName type="degree">PhD</roleName><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Zivadinov</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Associate Professor of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Director, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High St., Buffalo, NY 14203</p></note><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2233">2233</biblScope><biblScope unit="page" to="2241">2241</biblScope></imprint></monogr><idno type="istex">C02DE818BF537E2F5D675023C45334276547BA43</idno><idno type="DOI">10.1002/mds.22754</idno><idno type="ArticleID">MDS22754</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>MRI</term></item><item><term>brain atrophy</term></item><item><term>SIENAX</term></item><item><term>white matter hyperintensities</term></item><item><term>cognition</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-10-29">Received</change><change when="2009-07-27">Registration</change><change when="2009-11-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C02DE818BF537E2F5D675023C45334276547BA43/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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type="manuscriptAccepted" date="2009-07-27"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-09-18"></event><event type="firstOnline" date="2009-09-18"></event><event type="publishedOnlineFinalForm" date="2009-11-19"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText" date="2010-05-12"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2233</numbering><numbering type="pageLast">2241</numbering></numberingGroup><correspondenceTo>Associate Professor of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Director, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High St., Buffalo, NY 14203</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22754.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="44"></count><count type="wordTotal" number="6675"></count></countGroup><titleGroup><title type="main" xml:lang="en">Brain atrophy and white matter hyperintensities in early Parkinson's disease<link href="#fn19"></link></title><title type="short" xml:lang="en">Brain MRI in Early Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Turi O.</givenNames><familyName>Dalaker</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3 #af4 #af5"><personName><givenNames>Jan P.</givenNames><familyName>Larsen</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Niels</givenNames><familyName>Bergsland</familyName><degrees>BA</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Mona K.</givenNames><familyName>Beyer</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Guido</givenNames><familyName>Alves</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael G.</givenNames><familyName>Dwyer</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af5 #af6"><personName><givenNames>Ole‐Bjorn</givenNames><familyName>Tysnes</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af7"><personName><givenNames>Ralph H.B.</givenNames><familyName>Benedict</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Arpad</givenNames><familyName>Kelemen</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Kolbjorn</givenNames><familyName>Bronnick</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1 #af7" corresponding="yes"><personName><givenNames>Robert</givenNames><familyName>Zivadinov</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>rzivadinov@thejni.org</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NO" type="organization"><unparsedAffiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NO" type="organization"><unparsedAffiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="NO" type="organization"><unparsedAffiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">MRI</keyword><keyword xml:id="kwd3">brain atrophy</keyword><keyword xml:id="kwd4">SIENAX</keyword><keyword xml:id="kwd5">white matter hyperintensities</keyword><keyword xml:id="kwd6">cognition</keyword></keywordGroup><fundingInfo><fundingAgency>Buffalo Neuroimaging Analysis Center</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber># 186966</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Norwegian Society of Radiology</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Norwegian ParkWest</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Western Norway Regional Health Authority</fundingAgency><fundingNumber># 911218</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber># 177966</fundingNumber></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22754:supp_info_corrected_dalaker"></mediaResource><caption>Supporting Information.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn19"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Brain atrophy and white matter hyperintensities in early Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Brain MRI in Early Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Brain atrophy and white matter hyperintensities in early Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Turi O.</namePart><namePart type="family">Dalaker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan P.</namePart><namePart type="family">Larsen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Niels</namePart><namePart type="family">Bergsland</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mona K.</namePart><namePart type="family">Beyer</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guido</namePart><namePart type="family">Alves</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael G.</namePart><namePart type="family">Dwyer</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ole‐Bjorn</namePart><namePart type="family">Tysnes</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute of Clinical Medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ralph H.B.</namePart><namePart type="family">Benedict</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arpad</namePart><namePart type="family">Kelemen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kolbjorn</namePart><namePart type="family">Bronnick</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Zivadinov</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><affiliation>Department of Neurology, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA</affiliation><description>Correspondence: Associate Professor of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Director, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High St., Buffalo, NY 14203</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-11-15</dateIssued><dateCaptured encoding="w3cdtf">2008-10-29</dateCaptured><dateValid encoding="w3cdtf">2009-07-27</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">4</extent><extent unit="references">44</extent><extent unit="words">6675</extent></physicalDescription><abstract lang="en">The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Buffalo Neuroimaging Analysis Center</note><note type="funding">Research Council of Norway - No. # 186966; </note><note type="funding">Norwegian Society of Radiology</note><note type="funding">Norwegian ParkWest</note><note type="funding">Western Norway Regional Health Authority - No. # 911218; </note><note type="funding">Research Council of Norway - No. # 177966; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>MRI</topic><topic>brain atrophy</topic><topic>SIENAX</topic><topic>white matter hyperintensities</topic><topic>cognition</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>15</number></detail><extent unit="pages"><start>2233</start><end>2241</end><total>9</total></extent></part></relatedItem><identifier type="istex">C02DE818BF537E2F5D675023C45334276547BA43</identifier><identifier type="DOI">10.1002/mds.22754</identifier><identifier type="ArticleID">MDS22754</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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